摘要
给家兔一次性静注内毒素(700μg/kg),复制急性肺损伤动物模型,观察到家兔呈休克状态,外周血白细胞和血小板减少,血浆TXB_2和6-keto-PGF_(1α)升高,血清ACE活性一过性升高后进行性下降,肺毛细血管通透性增加,肺内粒细胞扣押、微循环障碍、内皮和上皮细胞受损等肺组织损伤改变。采用PGE_1治疗内毒素所致的家兔急性肺损伤有一定疗效。
A model of acute lung injury was reproduced by intravenous injection of endotoxin (700μg / kg) to rabbits. It had been found that the rabbits were in the state of shock, with leukopenia and thrombocytopenia, increased 6 -keto-PGF1α and TXB2, decreased serum ACE and increased permeability of the pulmonary capillaries. Granulocyte sequestration and disturbance in pulmonary microcirculation were found in lungs. A series of changes in epithelial and endothelial cells were also found in both lungs. It was obviously proved that PGE1 had some therapeutic effects in acute lung injury induced by E. coli endotoxin.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1993年第4期257-260,共4页
Medical Journal of Chinese People's Liberation Army
关键词
内毒素
肺损伤
前列腺素
血栓素
Endotoxin
Lung injury
PGE_1
TXA_2
PGI_2
Respiratory distress syndrome
