摘要
目的 对肝动脉栓塞后 ,门静脉分支对肝癌的营养情况进行观察。方法 将BrdU注入2 5例肝癌病人将被切除肝段的门静脉分支内 ,标本用BrdU单克隆抗体进行免疫组化染色 ,然后用标记指数 (LI)分析 ,同时检测被标记的S期细胞分布。结果 TAE病人的LI值比没有TAE的病人高 6倍 ,有显著差异 (P <0 0 0 1) ,标记的细胞不仅分布在肿瘤的周边部分 ,还分布在中心部分。结论 在TAE后的阶段 ,门静脉对残存的肝癌的血供发挥主要的作用 ,肝癌切除后的化疗不仅通过肝动脉而且应通过门静脉。
Objective To investigate the changes in nourishing vessels in hepatocellular carcinoma (HCC) after transcatheter arterial embolization (TAE). Methods BrdU was infused intraoperatively in 25 patients with HCC (12 without TAE and 13 after TAE) directly into the portal branch feeding the region to be resected. Specimens were prepared for immunohistochemical staining using BrdU monoclonal antibodies and analyzed using the labeling index (LI). The distribution of the labeled S-phase cells was also examined. Results The LI was significantly higher in the post-TAE patients than in those without TAE (P<0.001). Labeled cells were distributed not only peripherally but also in the central part of the tumor. Conclusions Some HCC cells are nourished by the portal blood flow directly throughout the viable tumor mass, which may act as the main blood supplier after TAE. After resection of HCC, the use of chemotherapy via not only the hepatic artery but also the portal blood flow is important.
出处
《中华肝胆外科杂志》
CAS
CSCD
2004年第3期154-155,共2页
Chinese Journal of Hepatobiliary Surgery
关键词
肝动脉栓塞
门静脉
肝癌细胞
营养情况
Carcinoma,hepatocellular
Portal vein
Transcatheter arterial embolization
