摘要
目的 探讨细胞黏附分子CD44变异体 6 (CD44V6)和纤维连接蛋白 (FN)的表达与泪腺肿瘤发生、发展和预后的关系及其临床病理学意义。方法 应用链霉亲和素 生物素 过氧化物酶复合物免疫组化法检测 4 9例泪腺良恶性肿瘤组织和 8例正常泪腺组织的CD44V6和FN蛋白的表达。并对检测结果进行比较。结果 CD44V6、FN蛋白在良性混合腺瘤的阳性表达率分别为 30 8% (8/ 2 6 )和80 8% (2 1/ 2 6 ) ,在泪腺恶性肿瘤的阳性表达率分别为 6 0 9% (14 / 2 3)和 34 8% (8/ 2 3) ,经统计学分析 ,恶性组的阳性表达率与良性组的阳性表达率差异有显著意义 (P <0 0 5 ) ;在复发肿瘤标本中 ,CD44V6、FN蛋白的阳性表达率与无复发组的阳性表达率比较 ,差异有显著意义 (P <0 0 5 ) ;两者表达呈显著负相关性 (P <0 0 1)。结论 CD44V6、FN在泪腺肿瘤的发生、发展及复发过程中发挥重要作用 ,且 2者的表达呈负相关性 ,检测CD44V6。
Objective To investigate the expression of cluster of differentiation 44 varia nt 6(CD 44V6) and fibronectin(FN) in lacrimal gland tumors. Meth ods Strept Avidin-Biotin Complex (SABC) immunohistochemistry met hod was used to study the expression of CD 44V6 and FN in 49 cases of lacr imal gland tumors .Results In benign lacrimal gland tum ors, the CD 44V6 and FN positive rates were 30.8%(8/26) and 80.8%(21/26 )respectively. In malignant lacrimal gland tumors , the CD 44V6 and FN po sitive rates were 60.9%(14/23)and 34.8%(8/23). The positive expression ra tes of CD 44V6 and FN in malignance were significantly different from benig n and control tissue. There is also a significant difference in the expression of CD 44V6 and FN in the cases of recurrence and non recurrence (P<0. 05) .Conclusions The expression of CD 44V6 and F N was correlated with the progress and recurrence of lacrimal gland tumors. The positive staining of CD 44V6 and FN was useful for differentiating malign ance from benignity and evaluating the progress and recurrence.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2004年第9期620-624,共5页
Chinese Journal of Ophthalmology
