摘要
分别观察艾迪注射液联合NP方案 (去甲长春花碱 +顺铂 )与单用NP方案治疗中晚期非小细胞肺癌 (non smallcelllungcancer ,NSCLC)的疗效及毒副反应。 68例NSCLC患者 ,随机分为两组 ,治疗组 3 4例 ,以艾迪注射液联合NP化疗方案治疗组 ,对照组 3 4例单用NP方案化疗。观察两组的治疗效果及毒副反应。两组的治疗效果差异无统计学意义 ,χ2 =0 0 63 3 ,P >0 0 5。治疗组在治疗后白细胞下降发生率 3 2 4% ( 11/3 4) ,对照组为 61 8% ( 2 1/3 4) ,差异有统计学意义 ,χ2 =5 90 2 8,P <0 0 5。治疗组血色素减少发生率 3 5 3 % ( 12 /3 4) ,对照组为 44 1% ( 15 /3 4) ,差异无统计学意义 ,χ2 =0 5 5 2 8,P >0 0 5。治疗组血小板减少发生率 2 3 5 % ( 8/3 4) ,对照组为 3 2 3 % ( 11/3 4) ,差异无统计学意义 ,χ2 =0 65 74,P >0 0 5。治疗组 3、4级恶心发生率 17 6% ( 6/3 4) ,对照组为 41 2 % ( 14 /3 4) ,差异有统计学意义 ,χ2 =4 5 3 3 3 ,P <0 0 5。治疗组 3、4级呕吐发生率 14 7% ( 5 /3 4) ,对照组为 3 5 3 % ( 12 /3 4) ,差异有统计学意义 ,χ2 =8 45 84,P <0 0 1。初步研究结果提示 ,艾迪注射液能减轻NP方案对骨髓的抑制作用 ,改善机体免疫力 ,减轻化疗所致的胃肠道反应 。
To evaluate the therapeutic effectiveness and adverse reaction of combined therapy of Aidi injection with NP in treating with non-small cell lung cancer. Methods Observation of combined therapy of Aidi injection with chemotherapy in treating non-small cell lung cancer was obtained from Mar.2003 to June. 2003.sixty and eight cases of non-small cell lung cancer were divided into two groups randomly: 34 cases (combined group) were treated with combined therapy of Aidi injection with NP while the other 34 cases (compared group) with only NP chemotherapy. Results there is not obvious discrimination of therapeutic effectiveness in the two groups. Anemia were 35.3%( 12/34) in the combined group, while in compared group the response rates were 44.1%(15/34), P>0.05. The thrombocytopenia were 23.5%(8/34) in the combined groups, while in the compared groups the descend rates were 32.4%(11/34). The nausea respond rates were 17.6%(6/34) in the combined groups, while in the other groups were 41.2%( 14/34), P<0.05.The vomiting rates of Aidi injection plus NP were 14.7% (5/34), which were lower than those of compared group (35.3%, 12/34,P<0.01). Leucopenia were 32.4% (11/34), while in compared group were 61.7% ( 21/34), P<0.05. Conclusions the combined therapy of Aidi injection and chemotherapy can alleviate the marrow reaction and digestive tract reactivity caused by chemotherapy, but can't improve the curative effect of chemotherapy.
出处
《肿瘤防治杂志》
2004年第10期1086-1088,共3页
China Journal of Cancer Prevention and Treatment
