摘要
背景与目的:随着肿瘤发病率的逐年增加,因颅内转移而导致死亡的病例数有所升高,而对于颅内转移瘤是否有手术指征尚存在争议。本文探讨开颅手术对颅内转移瘤的治疗价值。方法:回顾性分析我院近5年来手术后经病理证实的脑转移瘤的病理分型及预后。31例颅内转移性占位病灶。直径2.5～6.5cm,平均3.6cm。术前明确有肿瘤或肿瘤手术史22例,另9例术前肿瘤性质不明。结果:术后明确肿瘤来源于肺癌转移14例,消化道肿瘤转移6例,乳腺癌转移4例,血液系统肿瘤转移3例,泌尿系统精原细胞瘤转移2例,另2例病理为低分化癌和透明细胞癌,但原发病灶不清。结论:开颅手术治疗对于占位效应明显的脑转移瘤具有重要价值,不仅有助于明确病因,为进一步综合治疗提供指导,而且由于及时减压可挽救部分患者的生命,提高患者的生存质量,是脑转移瘤综合治疗的重要一环。
BACKGROUND & OBJECTIVE:With the increased incidence of cancer,the death rate that caused by brain metastasis steps up.The role of craniotomy in the treatment of brain metastases remains controver- sial.Hence,the effect of surgical intervention on the treatment of intracranial metastatic tumors is evaluated in this paper.METHODS:Thirty-one cases with intracranial metastatic tumors treated surgically were analyzed retrospec- tively in terms of their pathological findings and prognosis.The maximum diameter of cerebral metastases ranges from 2.5～6.5cm,with averaging 3.6cm.Twenty-two cases had definite tumor history while remained 9 cases were uncertain preoperatively.RESULTS:Pathological findings showed that tumors in 14 cases were from lung;6 cas- es from digestive tract;4 cases from breast cancer;3 cases from haematological malignancy;2 cases from semino- ma and remained 2 cases were from poorly differentiated cancer of unknown sources.After operation and further combined radiotherapy and chemotherapy,18 patients survived for more than one year and 7 patients more than two years.CONCLUSION:Surgical intervention is effective on the treatment of cerebral metastases by relieving intracranial hypertension crisis and making the diagnosis definite for a further combined therapy.
出处
《中国神经肿瘤杂志》
2004年第3期159-161,共3页
Chinese Journal of Neuro-Oncology
