摘要
目的 寻求急性毒鼠强中毒的有效综合救治措施。方法 将病例随机分为对照组 (n =2 4 )与实验组 (n =2 0 ) ,对照组采用血液灌流 (HP)和一般救治措施 ,实验组采用一般救治措施的同时应用二巯丙磺酸钠 (Na -DMPs)联合HP ,比较两组抽搐持续时间、昏迷持续时间、呼吸衰竭持续时间及血清谷丙转氨酶 (ALT)、磷酸肌酸肌酶 (CK)及其同工酶 (CK -MB)、肌酐 (Cr)等指标的变化。结果 实验组抽搐持续时间、昏迷持续时间、呼吸衰竭持续时间明显短于对照组 [(2 .1± 0 .7)dvs (3.7± 2 .2 )d、(2 8.7± 4 .6 )hvs(33.5± 10 .1)h、(2 .1± 0 .8)dvs (4 .3± 1.1)d ,P <0 .0 5 ];CK、Cr明显低于对照组 [(116 7.8± 5 3.1)U/Lvs(4 84 4 .4± 2 5 2 .7)U/L ,(370 .8± 4 1.4 ) μmol/Lvs (5 38.4± 6 5 .4 ) μmol/L ,P <0 .0 5 ) ];抽搐持续时间与CK、Cr呈正相关 (r=0 .86 3、0 .72 7,P <0 .0 5 )。结论 Na -DMPs联合HP救治急性毒鼠强中毒临床效果优于单纯HP ,能迅速控制抽搐、缩短昏迷时间 ,减少心、肝、脑、肾等器官的损害 ,值得临床推广应用。
Objective To explore an effective scheme to rescue acute tetramine poisoning. Methods Fourty-four cases were randomly divided into two groups the control group (n=24) and the test group (n=20). The patients in control group were given HP and routine therapy. The patients in the test group were given Na-DMPs, HP and routine therapy. The duration of twitch, coma and respiratory failure, CK, CKMB, ALT and Cr were observed and compared between the two groups. Results The twitch, coma, respiratory failure duration of the test group was shorter than the control`s[(2.1±0.7)d vs (3.7±2.2)d, (28.7±4.6)h vs (33.5±10.1)h, (2.1±0.8)d vs (4.3±1.1)d respectively P<0.05)]. CK and Cr were significantly lower than the control`s. CK and Cr had positive correlation with the twitch (r=0.863,0.727,P<0.05). Conclusions The treatment of acute tetramine poisoning with Na-DMPs accompanied by HP was better than only HP. It can control the twitch rapidly, shorten the coma duration, then alleviate the injury of heart, liver, brain and kidney.
出处
《中国血液净化》
2004年第10期543-545,578,共4页
Chinese Journal of Blood Purification
