摘要
目的 探讨新生儿缺血缺氧性脑病(HIE)脑脊液(CSF)环磷酸腺苷(cAMP)变化及其临床意义。方法 采用法国:Immunotech公司提供的125I-cAMP放免药盒对86例HIE患儿进行脑脊液cAMP。结果 中、重度HIE组CSI-cAMP值较非HIE组明显降低,有显著差异(P<0.05);重度HIE患儿CSI-cAMP值较轻、中度患儿降低,差异具有显著性(P<0.05);恢复期较急性期CSF-cAMP值都有所升高,但无显著差异。结论 HIE时CSF-cAMP降低,病情愈重,降低愈明显。CSF-cAMP测定可作为HIE患儿判断病情的辅助指标。
To study the variety of cAMP in cerebro-spinal fluid (CSF) and its clinical signifi-cance in newborn infants with hypoxic ischemic encephalopathy (HIE) . Methods The concentrations of CSF cAMP were measured by using 125I - cAMP radioimmunoassay procedures in 86 neonates with HIE. ResultS CSF cAMP levels in moderate and severe HIE groups were significantly lower than those of the non - HIE group (P <0.05). The CSF cAMP levels were significantly lower in the severe HIE groups compared to mild and moderate HIE groups ( P < 0.05) . CSF cAMP levels in recovery infants were high-er than those in acute period, but the differences had no statistic synificance. Conclusion The more severe HIE is, the lower the CSF cAMP level will be; CSF - cAMP test is a secondary marker to evaluate the situation of neonates with HIE.
出处
《新生儿科杂志》
2004年第4期152-154,共3页
The Journal of Neonatology
