摘要
目的 研究甲状腺功能减低状态 (简称甲减 )对人体血清白介素 - 6 (IL - 6 )、白介素 - 8(IL - 8)、肿瘤坏死因子 (TNF)水平的影响。方法 选初诊原发性甲减患者 5 3例及正常对照者 4 5例 ,抽取静脉血测定血清IL - 6、IL - 8、TNF水平。结果 (1 )甲减患者的IL - 6水平与正常对照组相比无显著差异 (P >0 .0 5 )。 (2 )甲减组中IL - 8浓度比对照组高 (P <0 .0 5 )。 (3)甲减的TNF含量比正常对照组高 (P <0 .0 5 )。 (4)甲减组患者IL - 6、IL - 8、TNF浓度与年龄、性别、甲功高低无关。结论 IL - 8、TNF系统参与原发性甲减的发病过程 ,参与自身免疫反应的免疫病理过程。
Objective To evaluate the effect of different status of thyroid function (hypothyroidism as well as euthyroid status ) on serum IL-6,IL-8, TNF levels. Methods Serum IL-6,IL-8,TNF levels of hypothyroidism patients、euthyroid controls were measured. Results (1)Serum IL-6 levels in hypothyroidism patients were not different from control groups (P>0.05).(2)Serum IL-8 levels in hypothyroidism were higher than those in normal groups(P<0.05).(3)Serum TNF levels in hypothyroidism patients were significantly higher than those in normal groups (F=6.15,P<0.05).(4)Serum IL-6,IL-8,TNF levels in males were not different from those in females in hypothyroidism patients,P>0.05. Those in hypothyroidism patients were not correlation with age. Conclusion IL-8,TNF participate in hypothyroidism pathogenic process and the autoimmune pathological process.
出处
《医师进修杂志》
北大核心
2004年第11期28-29,共2页
Journal of Postgraduates of Medicine
基金
2001年内蒙古自治区卫生厅科研基金项目项目批准号:(2001)181
