摘要
目的 :探讨p5 3、CerbB - 2、PCNA在女性生殖系统恶性肿瘤中表达与肿瘤的预后、生存期的关系 ,建立有效的判断疾病进展和预后的指标。方法 :采用S-P免疫组化法检测 73例女性生殖系统恶性肿瘤p5 3、CerbB - 2、PCNA表达 ,分析p5 3、CerbB - 2、PCNA表达与临床分期、病理类型及组织分化的关系。结果 :CerbB - 2阳性表达为 32 .8% ,与临床分期、病理学类型及组织分化有关 ;p5 3蛋白阳性表达为 37.1% ,与临床分期有关 ,与病理类型及组织分化无关 ;PCNA阳性表达为 89% ,与临床分期、组织分化有关。结论 :p5 3、CerbB - 2、PCNA联合检测可作为妇科恶性肿瘤是否存在潜在转移和预后判断的重要参考指标。PCNA作为与细胞分化相关的因素 ,可作为临床分期、预后估计和术后辅助化疗的指征之一。
Objectives:To c xplore the relationship between expressi on of p53,CerbB-2 and PCNA and prognosis ,survival time in patients with gynecolo gical cancers,and to establish a effecti ve index to predict disease advance and prognosis.Methods:The expression of p53,CerbB-2,and PCNA were detected in 73 cases of gynecological cancer by SP imm unohistochemistry method,and the relatio nship between their expression and clini cal staging,histologic types,tissue diff erentiation was analyzed.Results:The positivie Cerb B-2 expression was 32.8% which related w ith clinical staging,histologic types,an d tissue differentiation;the positve p53 expression was 37.1% which associated w ith its clinical staging;the positive PC NA expression was 89% which related with their clinical staging and tissue diffe rentiation.Conclusions:The combining examination of p53,CerbB-2,and PCNA can be an important parameters to predict po tential metastaisis and prognosis of gyn ecological cancer.As a factor associated with cell differentiation,PCNA can be o ne of the parameter for clinical staging ,prognosis,and adjunctive chemotherapy.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2004年第5期307-309,共3页
Journal of Practical Obstetrics and Gynecology
