摘要
[目的 ]探讨谷胱甘肽S 转移酶M1(GSTM1)和T1(GSTT1)基因多态性与儿童白血病遗传易感性的关系。 [方法 ]采用病例 对照研究方法和多重PCR技术检测病例组和对照组的GSTM1和GSTT1缺失基因型的分布频率。 [结果 ]病例组中GSTM1缺失基因型的分布频率明显高于对照组 (OR =2 .18,95 %CI :1.0 2～ 4.67)。在男性病例中GSTM1缺失基因型的比例高于对照组 (P <0 .0 5 )。GSTM1与GSTT1在儿童白血病的发病中无交互作用。 [结论 ]GSTM1缺失基因型可能是儿童白血病的重要危险因素 ,男性患儿尤为明显 ;GSTT1基因多态性可能与儿童白血病无关 ;
Objective To examine the relationship of genetic polymorphisms of glutathione S-transferase(GST) including GSTM1 and GSTT1 and the susceptibility to childhood leukemia.[Methods] The case-control study was conducted involving 61 patients and 63 controls. The genetic polymorphisms:GSTM1 and GSTT1 were detected with multiplex polymerase chain reaction(PCR). Stratification analysis was used to assess the interaction between GSTM1 and GSTT1 null genotypes.[Results] The results showed that the frequency of GSTM1 null genotype in cases was higher than that in controls with odds ratios(OR) 2.18(95% confidence interval:1.02～4.67). The proportion of GSTM1 null genotype in boy cases was higher than that of controls(P<0.05). The results from interaction analysis showed that GSTM1 null genotypes combined with GSTT1 null genotypes did not have interaction on the risk of childhood leukemia. [Conclusion] GSTM1 null may be an important host risk factor for childhood leukemia,whereas GSTT1 deletion was not associated with the risk to childhood leukemia. Furthermore,there was no significant interaction between GSTM1 and GSTT1 null genotypes to childhood leukemia.
出处
《环境与职业医学》
CAS
北大核心
2004年第4期258-260,共3页
Journal of Environmental and Occupational Medicine
