摘要
目的 :观察曲唑酮治疗抑郁症的临床疗效和不良反应。方法 :符合中国精神疾病分类方案与诊断标准第 3版抑郁发作诊断标准的患者 70例 ,分为治疗组和对照组各 3 5例 ,治疗组每晚给予曲唑酮 5 0～ 2 5 0mg ,po ,对照组每晚给予帕罗西汀 10～ 3 0mg ,po ,治疗 6周。用汉密顿抑郁量表评定疗效 ,以不良反应症状量表和实验室监测评定其安全性。结果 :曲唑酮起效较帕罗西汀慢 ,治疗结束后曲唑酮和帕罗西汀的有效率分别是 71.4%和 80 .0 % ,两组疗效差异无显著性 (P >0 .0 5 )。曲唑酮主要的不良反应是困倦和头晕。结论 :曲唑酮治疗轻、中度抑郁症安全 ,有效。
Objective:To survey the clinical therapeutic effectiveness and adverse reactions of trazodone in the treatment of depression. Methods:70 inpatients meeting the CCMD-3 diagnostic criteria for depression episode were assigned to 2 groups,the treatment group(n=35) and control group (n=35). Patients of the treatment group were given each 50-250 mg of trazodone qn PO, and those of the control group were given each 10-30 mg of paroxetine qn PO.The course of treatment in both groups lasted 6 weeks.The therapeutic effectiveness was assessed with the Hamilton depression scale, the safety rate was appraised with the treatment emergent symptom scale (TESS) and laboratory examinations. Results:It was shown that trazodone started later to act than paroxetine. At the termination of the course of treatment, the overall effective rates of trazodone and paroxetine were 71.4% and 80.0%, respectively, the difference being insignificant(P>0.05). The major adverse reactions of trazodone were lassitude and dizziness. Conclusion:Trazodone was shown to be effective and safe in the treatment of mild and moderate depression.
出处
《医药导报》
CAS
2004年第10期727-729,共3页
Herald of Medicine
