摘要
目的 观察补充锌制剂、维生素C对染砷小鼠肝脏组织超氧化物岐化酶 (SOD)水平、丙二醛 (MDA )含量的影响 ,比较这两种物质针对砷染毒小鼠的抗氧化作用的强弱。方法 昆明种小鼠饮用含砷水同时通过灌胃给予不同种类的抗氧化剂 ,8周后 ,测定小鼠肝脏SOD活性及MDA含量。结果 干预 8周后 ,测定小鼠肝脏组织的SOD活性及MDA的含量 ,可见维生素C组的小鼠肝SOD活性上升、MDA含量下降达到正常对照组水平 (P <0 .0 5 ) ,锌制剂组仅小鼠肝SOD活性上升 ,达到正常对照组水平 (P <0 .0 5 )而MDA含量与染毒对照组差异无统计学意义 (P >0 .0 5 )。结论 提示补充一定剂量的锌制剂、维生素C对染砷小鼠的脂质过氧化有拮抗作用 ,维生素C对慢性砷中毒的防治效果要优于锌制剂。
ObjectiveTo observe the effect of zinc and vitamin C supplement on SOD activities and MDA contents in the liver of mice exposed to arsenic and to compare the antioxidative ability of zinc and vitamin C. MethodKunming mice were given high arsenic water containing 100mg of NaAsO 2 per liter and were administered different kinds of antioxidative agents for eight weeks. The SOD activities, MDA contents in the liver were determined. ResultIntervention experiment of Zn and vitamin C were carried out on the mice exposed to As. The SOD activities, MDA contents in the liver were determined after eight weeks. It was showed that SOD activities increased while the MDA contents decreased in vitamin C group and only SOD activities increased in Zn group (compared with arsenic exposed control group, P<0.05); Compared with normal control group, there was no significant difference both in SOD activities and MDA contents in vitamin C group and only on SOD activities in Zn group (P>0.05). ConclusionThe result indicated that some doses of vitamin C and Zn agent could markedly antagonize in lipid peroxidation of the mice exposed to arsenic. Vitamin C exhibited a good effect of prevention in MDA contents increasing and protection of SOD activity on arsenic exposing mice.
出处
《地方病通报》
2004年第3期14-16,共3页
Endemic Diseases Bulletin
基金
新疆卫生厅青年基金 (2 0 0 1青 - 1 )
关键词
慢性砷中毒
锌制剂
维生素C
干预实验
Chronic arsenic
Zinc agent
Vitamin C
Intervention experiment
