摘要
目的 制作和评价大鼠手术后疲劳综合征模型。方法 完全模仿手术的全过程切除大鼠的部分肝脏。结果 70 %肝切除实验大鼠一般情况表现差 ,体力耐受力下降 ,出现一定程度的抑郁表现 ,并在营养学指标、小肠黏膜应激反应损伤和肝脏白蛋白基因表达方面发生明显改变。结论 切除 70 %肝脏制作大鼠动物模型 ,具有临床术后疲劳综合征的基本特征 。
Objective To establish and assess the rat model of postoperative fatigue syndrome (POFS). Methods The rat model of POFS was developed by the partial resection of the liver. The behavioral changes prior and post to operation, the disorder of nutritive intake after operation, stress reaction (pathological changes of mucous membrane in small intestine) and the hepatic albumin gene expression were observed. Results Low body temperature, lower sensitivity and reactivity were found. The serum levels of the iron, total protein, albumin, globulin and so on as the indexes of nutrition obviously dropped. The injury of the mucous membrane resulted from the stress reaction after the resection of the liver. The gene expression of the albumin decreased in the model group.Conclusion The experimental rat model of POFS by partial resection of the liver can be used for the investigation of POFS.
出处
《中国普外基础与临床杂志》
CAS
2004年第5期424-427,共4页
Chinese Journal of Bases and Clinics In General Surgery
基金
广东省中医药管理局科研项目 (编号 :0 995 11)~~
