摘要
用合成法制备了[2’,6’-~3H]除草醚和[2’,6’-~3H]草枯醚。以间溴氯苯(Ⅰ)为起始原料,经催化卤-氚取代反应制得[3,5-~3H]氯苯(Ⅱ);然后用硝酸-浓硫酸的混合物硝化(Ⅱ)得[3,5-~3H]对氯硝基苯(Ⅲ);最后使(Ⅲ)分别与2,4-二氯苯酚或2,4,6-三氯苯酚起缩合反应生成[2’,6’-~3H]除草醚(Ⅳ)和[2’,6’-~3H]草枯醚(Ⅴ),比活度分别为1.16TBq/mol和1.89TBq/mol,放化纯度均大于95％。
Preparation of [2',6'- 3H] nitrofen and [2',6'- 3H] chloronitrofen were described. [3,5- 3H] chlorobenzene (Ⅱ) was prepared by catalytic halogen- tritium exchange reaction from m- bromo- chlorobenzene (Ⅰ). Then (Ⅱ) was nitrated with a mixtrue of HNO3 and H2SO4 to give [3,5- 3H] P- chloronitrobenzene (Ⅲ). Finally (Ⅲ) was condensed with 2,4- dichlorophenol or 2,4,6- trichlorophenol to form [2',6'- 3H] nitrofen(Ⅳ) and [2',6'- 3H] chloronitrofen (Ⅴ). The specific activity of tritiated nitrofen and chloronitrofen was 1.16 and 1.89 TBq/mol respectively, both radiochemical purities were over 95%.
出处
《核技术》
EI
CAS
CSCD
北大核心
1993年第1期47-51,共5页
Nuclear Techniques
基金
国家自然科学基金
关键词
除草剂
除草醚
草枯醚
合成
Weed killer [2',6'- 3H] nitrofen [2',6'- 3H] chloronitrofen
