摘要
目的 :探讨免疫抑制剂对矽肺发病的影响。方法 :动物采用随机法 ,分对照组 ,免疫抑制组。石英粉尘非暴露式吸入4周后 ,测定肺巨噬细胞功能 ,气管、支气管、肺显微镜观察。结果 :免疫抑制组肺巨噬细胞吞噬功能受到明显抑制 ,肺内细胞结节增多 ,肺细支气管等管壁增厚并胶原纤维增生。结论 :免疫抑制剂可加重矽肺的病程。
Objective:To investigate the effects of immunosuppressant on the development of silicosis.Methods:20rats were divided into immunosuppression group and control group.All of them were adopted by intratracheal instillated of silicasuspension for4weeks.The phagocytic function of pulmonary macrophage was detected and the morphology of trachea,bronchus and lung was observed.Results:The phagocytic function of pulmonary macrophage in the immunosuppression group was obviously subjected to suppression.Cellular codes with many inflammatory cells such as macraphage,mast cell and lymphocyte were increased compared with those in the control group.Conclusion:Immunosuppressant may increase the course of disease of silicosis.
出处
《现代医药卫生》
2004年第18期1845-1846,共2页
Journal of Modern Medicine & Health
