摘要
目的 探讨干扰素治疗前后 ,慢性乙型肝炎患者肝组织中细胞间粘附分子 - 1 (ICAM- 1 )的表达与组织学变化。方法 于干扰素治疗前 1周内和治疗 6个月结束后 1周内 ,取 36例慢性乙型肝炎患者的肝脏活检组织 ,评估肝组织学活动指数 (HAI) ,采用免疫组化 SP法检测肝组织中 ICAM- 1和 HBs Ag、HBc Ag的表达情况。结果 治疗后 38.9% (1 4 / 36 )的患者有应答反应 ,与治疗前相比干扰素治疗后慢性乙型肝炎患者肝组织学活动指数、ICAM- 1和 HBc Ag的表达均有明显下降 (P<0 .0 5 ) ,无应答反应者与治疗前相比 ,上述 3项指征均无明显变化 (P>0 .0 5 )。结论 干扰素治疗可调控细胞 ICAM- 1的表达 ,抑制或减少肝细胞中 HBV的复制及表达 。
Objective To explore the expression of ICAM 1 and histology change in liver tissues of the patients with chronic hepatitis B after interferon treatment. Methods Thirty six patients with chronic hepatitis B were enrolled in this research. Liver biopsy was performed on each patient in one week before treatment and one week after six months' treatment respectively. The expressions of ICAM 1, HBsAg and HBcAg were determined by SP immunohistochemistry, as well as liver histology activity index(HAI) was evaluated. Results The patients responded to interferon accounted for 38.8% (14/36). Compared with pretreatment, the expressions of ICAM 1 and HBcAg decreased significantly ( P <0.05) after treatment, so did the HAI in liver. The expressions of ICAM 1, HBcAg and the HAI had no apparent changes( P >0.05) compared with pretreatment. Conclusions Interferon treatment can regulate the expression of ICAM 1 in hepatocytes and inhibit or reduce the replication of HBV in liver. So we conclude interferon treatment can repress the inflammation activity degree of liver tissue in the patients with chronic hepatitis B.
出处
《东南国防医药》
2004年第4期248-250,共3页
Military Medical Journal of Southeast China
基金
福建省漳州市科技基金资助课题 (Z0 2 0 5 0 )
