摘要
目的:分析胸腔积液患者胸水中白细胞介素—6(IL—6)、C反应蛋白(CRP)水平,探讨两指标及其联合检测在胸腔积液性质鉴别诊断中的价值。方法:将97例不同病因的胸腔积液患者分成漏出液组、良性渗出液组及恶性渗出液组,平行检测胸腔积液中IL—6、CRP水平,并通过受试者工作特征曲线(ROC)进行评价。结果:良性渗出液组IL—6、CRP值明显高于漏出液和恶性渗出液组(均P<0.01);恶性渗出液组IL—6、CRP值明显高于漏出液组(均P<0.01)。分别以95 pg/ml、12.5mg/L作为IL—6、CRP诊断渗出液与漏出液的临界值。诊断渗出液的敏感度分别为95.5%、91.0%;特异性分别为93.3%、96.0%。两指标联检,诊断渗出液的敏感度为97.0%,特异性为100%。结论:胸腔积液IL—6、CRP检测及其联合检测对鉴别胸腔积液性质有一定的实用价值。
objective: To determine the levels of Interleukin-6 (IL-6), C-reactive protein (CRP) in pleural effusion in patients with pleural effusion , to evaluate the values of two indices and the union of both in diagnosing the property of pleural effusion. Methods:97 cases with differential diagnostic pleural effusion were divided into transudatory pleural, benign exudative and malignant exudative groups. IL-6,CRP were simultaneously determined in three groups,and the values of two indices were evaluated by receiver operator charateristic curve (ROC). Results: The levels of CRP.IL-6 in benign exudative group were significantly higher than those in transudatory pleural and malignant exudative pleural effusion groups (P<0.01). The levels of CRP and IL-6 in malignant exudative pleural group were higher than those in transudatory pleural group (P<0.01); Regarding 95 pg/mL as the cutoff value of IL-6 and 12.5mg/L as that of CRP to distinguish exudative pleural effusion from transudatory pleural effusion, the sensitivities in diagnosis exudative pleurat effusion were 95.5% ,91.0%,and specialities were 93.3%, 96.0% respectively. The uion of two indices would improve the sensitivity to 97.0% and speciality to 100% in diagnosing exudative pleural effusion. Conclutions: There are diagnostic values in IL-6, CRP and the union of this two indices for identifying the property of pleural effusion.
