摘要
将 5 2例局部晚期非小细胞肺癌 (non smallcelllungcancer,NSCLC)患者随机分为化放组和单放组 ,每组 2 6例。化疗方案为紫杉醇 13 5mg/m2 ,d1、d2 2 ;顺铂 2 0mg/m2 ,d1～d5、d2 2 ～d2 6,化疗同步60 Co体外照射 ,常规分割照射DT40Gy时缩野行加速超分割照射 ,DT1 5Gy/次 ,2次 /d ,2次间隔 >6h ,每周 5d ,照射 9d ,DT2 7Gy ,总剂量DT67Gy/ 6w。化放组CR、PR、NC和PD分别为 3 4 6% ( 9/ 2 6)、 5 3 8% ( 14 / 2 6)、7 7% ( 2 / 2 6)和 3 9% ( 1/ 2 6) ,有效率CR +PR为88 4% ( 2 3 / 2 6) ;单放组CR、PR、NC和PD分别为 19 2 % ( 5 / 2 6)、46 2 % ( 12 / 2 6)、2 3 1% ( 6/ 2 6)和 11 5 % ( 3 / 2 6) ,有效率CR +PR为 65 4% ( 17/ 2 6) ,P <0 0 5。化放组 1、2年生存率及中位生存时间分别为 69 2 %、3 8 5 %和 19个月 ,单放组分别为 46 1%、19 2 %和 12个月 ,P <0 0 5。化放组白细胞减少发生率 88 5 % ( 2 3 / 2 6) ,脱发发生率 10 0 % ,放射性食管炎 3 4 6% ( 9/ 2 6) ,放射性肺炎 2 3 1% ( 6/ 2 6) ;单放组白细胞减少发生率 3 0 8% ( 8/ 2 6) ,放射性食管炎 3 0 8% ( 8/ 2 6) ,放射性肺炎 19 2 % ( 5 / 2 6)。初步研究结果提示 ,紫杉醇
Concurrent chemotherapy with late course hyperfractionated accelerated radiotherapy (CCT+LCHAR) group,26 cases and LCHAR alone group,26 cases.The chemotherapy region was taxel 135 mg/m 2, intravenous infusion 3 hours, d 1,d 22 , DDP 20 mg/m 2 d 1-d 5, d 22 -d 26 . The patients received a fraction of 2 Gy daily, 5 days per week, to total dose of 40 Gy during the conventional fractionated radiotherapy, and then followed by LCHAR: 1.5 Gy, twice daily, with the interval of 6-8 hours between fractions to total dose of 67 Gy/6 weeks. The overall response rate,the 1- and 2-year survival rates were 88.4%, 69.2%, 38.5% in the CCT+LCHAR group and 65.4%, 46.1%, 19.2% in the LCHAR group,P<0.05. The median survival time was 19 months and 12 months in the CCT+LCHAR group and LCHAR group, respectively,P<0.05. The frequencies of side effects such as leukocytopenia, pneumonitis, esophagitis, were 88.5%,23.1%,34.6% in the CCT+LCHAR group and 30.8%,19.2%,30.8% in the LCHAR group, respectively. There was no ocurrance of Ⅳ degree toxicities in all patients. The concurrent chemotherapy combined with late course hyperfractionated accelerated irradiotherapy could be tolerated with the assist treatment of G-CSF. The immediate response was encouraging.
出处
《肿瘤防治杂志》
2004年第9期966-968,共3页
China Journal of Cancer Prevention and Treatment
关键词
癌
非小细胞肺/药物疗法
癌
非小细胞肺/放射疗法
综合疗法
存活率
carcinoma,non-small cell lung/drug therapy
carcinoma,non-small cell lung/radiotherapy
combined modality therapy
survival rate
