摘要
目的研究抑郁患者血清皮质醇浓度、血压在应激前后的变化以及它们之间的关系。方法分别在安静状态、心理应激状态和心理应激后 (恢复状态 )测量抑郁组和对照组的血清皮质醇浓度、血压 ,比较两组上述指标的差异 ,以及心理应激前后的变化。心理应激以规定时间内的计算试验模拟 ,血清皮质醇以酶联免疫试验检测 ,血压为常规检测。结果 1.皮质醇 :抑郁组在安静状态、应激状态、恢复状态的皮质醇浓度显著高于对照组 (P <0 .0 5 ) ,抑郁组应激前后皮质醇浓度的波动显著小于对照组 (P <0 .0 5 )。2 .收缩压 :安静状态和恢复状态时抑郁组的收缩压显著高于对照组 (P <0 .0 5 ) ,应激状态时两组无统计学差异 ;应激前后收缩压的波动两组无统计学差异。 3 .舒张压 :抑郁组在安静状态时舒张压显著高于对照组(P <0 .0 5 ) ,在应激状态和恢复状态时两组无统计学差异 ;应激前后舒张压的波动两组无统计学差异。结论抑郁患者存在基础血压升高 ,此现象可能与抑郁患者血清皮质醇浓度升高有关。
ObjectiveTo study the variety of cortisol level and blood pressure of depression patients during the stress. Methods Evaluatedthe plasma cortisol level、blood pressure of depression patients and controls when they were in quiet state, stress state, after stress state,respectively. The stress was modeled with the calculating model, the plasma cortisol level was tested by ELISA. Results 1. The plasma level of cortisol of depression patients in quiet, stress, after stress was markedly higher than that in controls, respectively.In depression group, the alteration of plasma cortisol level during stress was less than that of control group. 2. The systolic pressure of depression patients was higher than controls in quiet state and post stress state, that in stress state was not significantly different between two group. There was no significant difference between depression group and control group in the alteration of systolic pressure during stress. 3. The diastolic pressure of depression was higher than controls in quiet state, that in stress state and post stress state was not significantly different between two group. There was no significant difference between depression group and control group for alteration of diastolic pressure during stress. Conclusion The blood pressure of depression patients is higher than that of controls, the phenomenon is likely related with the high cortisol level of depression patients.
出处
《中国行为医学科学》
CSCD
2004年第5期524-525,共2页
Chinese Journal of Behavioral Medical Science
关键词
抑郁患者
血清皮质醇
血压
应激
Depressive disorder
Cortisol
Blood pressure
Stress
