期刊文献+

胰岛素样生长因子与生长发育的研究进展 被引量:7

Advance in relation between insulin-like growth factor and growth development
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摘要 胰岛素样生长因子 (IGFs)及其受体、结合蛋白、结合蛋白酶构成IGF轴 ,在儿童生长发育中起重要作用。IGFs通过自分泌和旁分泌机制对肌母细胞、成骨细胞、脂肪细胞、神经细胞、造血细胞等的增殖分化起调节作用 ;IGFs还能促进蛋白质的合成、葡萄糖氧化与脂肪分解 ;同时促进免疫细胞的分化与成熟 ,保护肠道黏膜屏障 。
作者 高珊 毛萌
出处 《国外医学(儿科学分册)》 2004年第5期269-271,共3页 Foreign Medical Sciences(Section of Pediatrics)
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参考文献15

  • 1Szkudlarek J,Jeppesen PB,Mortensen PB.Effect of high dose growth hormone with glutamine and no change in diet on intestinal absorption in short bowel patients:a randomised,double blind,crossover,placebo controlled study[J].Gut,2000,47(2):199-205. 被引量:1
  • 2Valentinis B,Romano G,Peruzzi F,et al.Growth and differentiation signals by the insulin-like growth factor-binding 1 receptor in hemopoietic cells are mediated through different pathways[J].J Biol Chem,1999,274(18):12423-12430. 被引量:1
  • 3Holzenberger M,Hamard G,Zaoui R,et al.Experimental IGF-I receptor deficiency generatey a sexually dimorphic pattern of organ-specific growth deficits in mice,affecting fat tissue in particular[J].Endocrinology,2001,142(10):4469-4478. 被引量:1
  • 4Read LC,Lemmy AB,Howarth GS,et al.The gastrointestinal tract is one of the most responsive target tissues for IGF-I and its potent analogs. In:Spencer EM,eds.Modern concepts of Insulin-like growth factors[C].New York:Elsevier,1998:225-234. 被引量:1
  • 5Lorraine E,Kate L,Cohen P.Fetal and Neonatal Physiology[M].I Fox PR.2eds.Philadelphia:WB Sauders Co.1998.2401-2409. 被引量:1
  • 6van Kleffens M,Croffen C,Rosato RR,et al.mRNA expression pattems of the IGF system during mouse limb bud development,determined by whole mount in situ hybridization[J].Mol Cell Endocrinol,1998,138(1-2):151-161. 被引量:1
  • 7Twigg SM,Kiefer MC,Zapf J,et al.A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit[J].Endocrinology,2000,141(1):454-457. 被引量:1
  • 8Hoeflich A,Fettscher O,Lahm H,et al.Overexpression of insulin-like growth factor-binding protein-2 result in increased tumorigentic potential in Y-1 adrenocortical tumor cells[J].Cancer Res,2000,60(4):834-838. 被引量:1
  • 9Zumkeller W,Westphal M.The IGF/IGFBP system in CNS malignancy[J].Mol Pathol,2001,54(4):227-229. 被引量:1
  • 10Rajah R,Bhala A,Nunn SE,et al.7S Nerve growth factor is an insulin-like growth factor-binding protein protease[J].Endocrinology,1996,137(6):2676-2680. 被引量:1

二级参考文献1

  • 1吴瑞平 胡亚美 江载芳 主编.诸福棠实用儿科学:第六版[M].北京: 人民卫生出版社,1996.14-46. 被引量:1

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