摘要
目的 探讨矿物质元素钙、镁、锌、铁、铬和维生素A、B1、B2、C、D、E对膳食诱导肥胖大鼠代谢影响。方法 利用高能饲料诱导大鼠肥胖模型后 ,观察部分矿物质营养素钙、镁、锌、铁、铬和维生素A、B1、B2、C、D、E对肥胖大鼠代谢的影响。血糖采用试纸法测定 ;应用酶法测定血脂 ;放射性免疫法测定胰岛素、瘦素的含量。结果 B组体重和脂体比显著高于其它各组 ,D组和E组体重增加的趋势明显降低 ,二者较接近且略高于A组 ,C组在实验中后期体重的持续下降可能与机体必需的矿物质元素和维生素长期摄入不足有关 ,而非生理状态下的减重 ,其各项代谢指标均出现下降 ;无论血糖、血脂、胰岛素还是瘦素 ,与E组相比 ,D组都有更明显的降低趋势。结论 膳食矿物质元素钙、镁、锌、铁、铬和维生素A、B1、B2、、C、D、E对肥胖大鼠体重和体脂含量没有更明显的减低作用 ,但可以有效地降低肥胖大鼠的高血糖和高血脂 ,改善高胰岛素血症和高瘦素血症 。
Objective To explore dietary mineral nutrients (calcium,magnesium,zinc,ferric,chromium)and vitamins(vitamin A,B 1,B 2,C,D,E)on the effect of metabolic disordor of Wistar rat fed with high fat diet. Methods\ Fifty obesity prone male rats were randomly divided into 5 groups:A group were fed with basic diet,B group were fed with high fat diet and normal minerals and vitamins,C group were fed with high fat diet with lower minerals and vitamins,D group were fed with high fat diet with higher minerals and vitamins,E group were fed with high fat diet with only higher calcium.After 8 weeks,blood glucose,serum insulin and leptin,serum triglycerides,cholesterol and high density lipoprotein were measured respectively. Results\ The body weight and fat content in B group were significantly higher than those of other groups.The body weight in D,E group decreased significantly compared with B group, both of which are similar with A group. In the case of blood glucose, serum insulin ,leptin,triglycerides,cholesterol and high density lipoprotein, they all have the tendency of decreasing in D group compared with E group. Conclusion In addition to reducing body weight and fat content,dietary mineral nutrients and vitamins can also ameliorate the blood glucose and improve hyperinsulinemia and hyperleptinemia, modify the metabolic disordor of rat fed with high fat diet.
出处
《卫生研究》
CAS
CSCD
北大核心
2004年第4期447-449,共3页
Journal of Hygiene Research
基金
国家自然科学基金资助项目 (No .30 0 70 655)
