摘要
目的 :研究 6 ,7 二氟 1 甲基 4 氧代 4H [1,3]硫氮杂环丁烷并 [3,2 α]喹啉 3 羧酸乙酯的合成工艺改进方法。方法 :以 6 ,7 二氟 4 羟基 2 硫乙基 喹啉 3 羧酸乙酯为原料经乙酰化、氯代、环合步骤制备目标产物。结果 :该方法工艺简单 ,后处理方便 ,且反应条件温和。结论
Objective: To study the preparation of ethyl 6,7-difluoro-1-methyl-4-oxo-1, 4-dihydro-[1,3] thiazeto [3,2-α] quinoline-3-carboxylate. Methods: The ethyl 6,7-difluoro-1-methyl-4-oxo-1,4-dihydro-[1, 3] thiazeto[3, 2-α]quinoline-3-carboxylate is prepared from ethyl 2-(ethylthio)-6, 7-difluoro-4-hydroxyquino- line-3-carboxylate through acetylation and cyclization. Results: This method is simple and convenient. The re- acting condition is moderate. Conclusion: This synthesis route is practical and easy to popularize in industry.
出处
《药学进展》
CAS
2004年第7期325-327,共3页
Progress in Pharmaceutical Sciences
关键词
硫氮杂环丁烷
羧酸乙酯
合成工艺
抗菌药
Synthesis,Ethyl 6,7-difluoro-1-methyl-4-oxo-1,4-dihydro-[1, 3] thiazeto[3, 2-α]quinoline-3-carboxylate, Ethyl 2-(ethylthio)-6, 7-difluoro-4-hydroxyquinoline-3-carboxylate
