摘要
目的观察长春瑞滨(NVB)联合顺铂(DDP)组成NP方案治疗35例非小细胞肺癌(NSCLC)的疗效和不良反应。方法NVB25～30mg/m2静脉注射第1,8天,DDP80mg/m2分3天(第1～3天)静脉滴注,21天为一周期,连用3个周期。结果完全缓解0例,部分缓解13例,无变化16例,进展6例,总有效率37.1%,缓解期3～12月,中位缓解7个月,主要毒性反应为骨髓抑制和胃肠道反应,III、IV度白细胞下降率为62.9%,局部疼痛或静脉炎发生率20%,无治疗相关性死亡。结论采用NP方案治疗晚期NSCLC的有效率较高,不良反应可以耐受,可作为临床治疗NSCLC的一线方案。
objective To evaluate the therapeutic effect of combination chemotherapy with vavelbine(NVB) and cisplatin (DDP)(NP regimen) in patients with advanced non-small cell lung cancer (NSCLC).Methods 35 cases of advanced NSCLC were treated with NP regimen in this study,11 patients had receivedprior chemotherapy while 24 had not. NVB 25～30mg/m2, day 1and day 8, DDP 80mg/m2, day 1 ,day2 and day3,a cycle was 21 days, Effect was evaluated after 3 cycles. The therapeutic effect and side-effect wereobserved strictly on each patient.Results Response rate (RR) was observed in 37.1% of patients, themedium response duration was 7 months . Side effects were mainly myleosuppression and digestive tractreaction, neutropenia with grade III and IV was 62.9% of the patients. The local venous toxicity wasobserved in 20% of the patients,without treatment-related deaths. conclusion A higher response rateis attainable in patients with advanced NSCLC by treatment with NP regiment,Toxicity was tolerable.
出处
《国际医药卫生导报》
2004年第14期29-31,共3页
International Medicine and Health Guidance News
关键词
非小细胞肺癌
化学治疗
长春瑞滨
顺铂
Non-small cell Lung cancer Chemotherapy Vavelbine Cisplatin
