摘要
目的观察长春瑞滨(NVB)联合顺铂(DDP)对晚期非小细胞肺癌的近期疗效及毒副反应。方法对57例晚期非小细胞肺癌(NSCLC)患者采用 NVB 联合 DDP 治疗:NVB 25 mg/m^2,静脉冲入,第1、5天;DDP 30 mg/m^2,静脉点滴,第1～3天;21天为一周期,至少治疗2周期以上。结果全组 CR 0例,PR 27例,总有效率(CR+PR)为47.4%(27/57)。毒副反应主要为白细胞下降,Ⅰ～Ⅱ度59.6%(34/57),Ⅲ～Ⅳ度17.5%(10/57),其他不良反应较轻微。结论 NP 方案治疗晚期 NSCLC 疗效较好,不良反应可以耐受。
Objective To investigate the short-term clinical effects of combination chemotherapy with vi- norelbine(NrVB)and cisplatin(DDP)in patients with advanced stage non-small cell lung cancer(NSCLC).Meth- oils 57 patients with advanced stage NSCLC were treated by NVB and DDP:NVB 25mg/m^2 iv on days 1 and 5,DDP 30 mg/m^2 iv on days 1～3,21 days a ctcles for more than two cycles.Result The overall response rate (CR+PR)was 47.4%(27/57)with 0 case CR and 27 cases PR.The dose limiting toxicity was neutropenia which was seen 59.6%(34/57)in grades Ⅰ～Ⅱ,17.5%(10/57)in grades Ⅲ～Ⅳ.Other toxicity was acceptable.Conclusion A high response rate was obtained in advanced NSCLC treated with NP regime.
出处
《基层医学论坛》
2003年第10期874-876,共3页
The Medical Forum
关键词
长春瑞滨
顺铂
非小细胞肺癌
Vinorelbine
Cisplatin
Non-small cell lung cancer
