摘要
目的:合成头孢替安中间体2-甲酰氨基-噻唑基-4-乙酸;方法:以2-氨基-噻唑基-4-乙酸乙酯为原料,经甲酰化、水解两步反应制备得到。用 IR 进行结构鉴定;结果:总收率为70%;结论:本方法工艺条件温和,收率高,成本低,适合工业化生产。
Objective:To synthesize acido 2-formammidotiazol-4-il acetico,an intermediate of Cefotiam;Methods-acido 2-formammidotiazol-4-il acetico was synthesized from acido 2-ammidoti- azol-4-il acetico,etil estere by two steps:carbamoyl and hydrolysis.The structure is detected by IR;Resuhs:the total yield is 70%;Conclusion:This method is moderate and the yield is higher, the price is lower and fit for industrial production.
出处
《黑龙江医药》
CAS
2004年第4期285-286,共2页
Heilongjiang Medicine journal
