摘要
目的 探讨经肝动脉灌注32 P 玻璃微球内照射栓塞治疗肝癌的吸收剂量估算方法。方法 肝癌患者 30例 ,采用改良式Seldinger技术行超选择性插管 ,经导管灌注32 P 玻璃微球、超液化碘油和吡柔比星的混悬液。术后行 β轫致辐射显像 ,观察32 P 玻璃微球的分布 ,结合分区模型和32 P内照射吸收剂量公式 ,估算肿瘤、非瘤肝组织和肺组织的吸收剂量。结果 肿瘤组织的平均吸收剂量为 (130 34± 5 4 5 3)Gy ,非瘤肝组织为 (34 73± 13 4 1)Gy;肺组织为 (6 8± 4 9)Gy。肿瘤吸收剂量 >12 0Gy者 13例 ,反应率 10 0 % ,中位生存期 2 1个月 ;<12 0Gy者 17例 ,反应率 4 7 1% ,中位生存期 11个月。结论 经肝动脉超选择性灌注32 P 玻璃微球内照射化疗栓塞治疗肝癌是一种安全有效的方法。术后 β轫致辐射显像结合分区模型估算肿瘤组织和非瘤肝组织的吸收剂量可行。
Objective To study the method of estimating radiation doses and its application in clinical research of intra-arterial radioembolization with 32 P-glass microspheres for treatment of liver cancer. Methods Thirty patients with liver cancer were catheterized using Seldinger's technique, and super-selective catheterization was performed. Through the catheter, the suspension of mixed 32 P-glass microspheres, lipiodol-ultrafluid (5～20 ml) and pirarubicin (10 mg) was infused. β bremsstrahlung imaging was performed after treatment to observe the distribution of 32 P-glass microspheres. Combining partition model and formula of radiation doses of internal radiation with 32 P-microspheres, radiation doses in tumor, normal liver tissue and lung tissue were estimated, respectively. Results The mean radiation doses were (130.34±54.53) Gy in tumors, (34.73±13.41) Gy in normal liver tissue, and (6.8±4.9) Gy in lung tissue. The rate of response was 100%, median survival period was 21 months in 13 patients who received radiation doses of >120 Gy to tumors, and 47.1%, 11 months in 17 patients who received radiation doses of <120 Gy to tumors. None radiation pneumonitis was found. Conclusions Super selective intra-arterial radioembolization with 32 P-glass microspheres is an effective and safe method in treatment of liver cancer. Estimation of radiation doses in tumor, normal liver tissue and lung tissue with β bremsstrahlung imaging and partition model is a practical method for radiation dose research.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2004年第3期181-183,共3页
Chinese Journal of Nuclear Medicine
基金
天津市自然科学基金资助项目 (0 0 360 71 1 1 )
关键词
经动脉灌注
^32P-玻璃微球
治疗
肝癌
吸收剂量
估算
Liver neoplasms
Radiotherapy
Phosphorus radioisotopes
Glass microsphere
Radiation dosage
