摘要
目的评价左旋氧氟沙星(左氟沙星,levofloxacin,LVLX)治疗胆道系统急性细菌性感染的有效性和安全性。方法选择急性胆道感染患者,随机分为试验组和对照组,试验组静脉滴注左氟沙星400mg,每天1次,疗程7～14d,对照组静脉滴注头孢噻肟钠(cefotaxinesodium)2,3g,每天3次,疗程7～14d。结果左氟沙星与头孢噻肟钠在痊愈率、有效率、细菌清除率、阴转率及不良反应率等方面差异无统计学意义(>0.05),但同期用药量前者更少(<0.05)。结论左氟沙星治疗胆道系统急性细菌性感染安全有效,有临床应用价值。
Objective: To evaluate the clinical efficacy and safty of levofloxacin (LVLX) in treatment of acute bacterial infection in biliary system. Methods: The patients with acute bile duct infection were enrolled in randomly trials; Trial group: 400 mg levofloxacin was given by intravenous drip once a day for 7～14 days, control group: 2, 3 g cefotaxine sodium was given by intravenous drip three times a day for 7～14 days. Results: In the following aspects including the cure rates, the effective rates, the bacterial clearance rate, transforming negative rate of bacteria and incidence rate of adverse effects, the difference of levofloxacin and cefotaxin had no statistical significance (P>0.05). Conclusions: Levofloxacin can be employed to treat acute bacterial infection in biliary system effectively and safely, deserving clinical application.
出处
《中国现代医学杂志》
CAS
CSCD
2004年第12期56-58,共3页
China Journal of Modern Medicine
关键词
左旋氧氟沙星
头孢噻肟钠
胆道
细菌感染
随机对照试验
levofloxacin (LVLX)
cefotaxine
bile duct
bacterial infection
randomly controlled trial
