摘要
目的 研究子宫肉瘤雌、孕激素受体的表达情况以及其临床生物学意义。方法 选取 1 991年9月～ 2 0 0 1年 9月北京大学人民医院及第三医院收治的子宫肉瘤患者 4 4例 ,选取石蜡病理切片 ,用免疫组化法测定ER、PR表达情况。结果 ①ER表达阳性率在子宫内膜间质肉瘤中为 75 % ,子宫平滑肌肉瘤为 31 8% ,子宫恶性苗勒管混合瘤为 2 /6。子宫内膜间质肉瘤ER表达阳性率显著高于子宫平滑肌肉瘤 (P <0 0 5 ) ;②PR表达阳性率在子宫内膜间质肉瘤中为 1 0 0 % ,子宫平滑肌肉瘤为 6 8 2 % ,子宫恶性苗勒管混合瘤为 3/6。子宫内膜间质肉瘤的PR表达阳性率显著高于子宫平滑肌肉瘤及恶性苗勒管混合瘤 (P <0 0 5 ) ;③与临床病理学特征的关系 :ER与PR间呈显著正相关性。无瘤存活者ER、PR表达率显著高于因瘤死亡者 (P <0 0 5 )。核分裂 <1 0个 /1 0HPs的子宫肉瘤PR表达阳性率显著高于核分裂≥ 1 0个 /1 0HPs的子宫肉瘤 (P <0 0 5 )。结论 ①子宫内膜间质肉瘤ER、PR阳性率均显著高于子宫平滑肌肉瘤和子宫恶性苗勒管混合瘤 ,子宫内膜间质肉瘤患者可常规进行ER、PR测定 ,根据ER及PR表达情况辅助激素治疗 ;②无瘤存活者ER、PR表达率显著高于因瘤死亡者 ,说明ER。
Objective To investigate the expression of estrogen receptor and progesterone receptor, and their significance in clinical-biological properties of uterine sarcoma.Methods Forty-four patients with uterine sarcoma who were admitted in Peking University People's Hospital and the Third Hospital during Sep.1991-Sep.2001 were studied.The expressions of ER and PR were detected immunohistochemically in formalin-fixed and paraffin-embedded tissue.The relationship between the positive rate of ER, PR expression and the clinic-pathologic characteristics was analyzed.Results ① The positive rate of ER was 75 0% (12/16)in endometrial stromal sarcoma which was significant higher than that of in leiomyosarcoma(31 8%)( P <0 05).Two of six patients were ER expression positively in mixed Mullerian tumour.② All cases(16 cases)were PR positive expression in endometrial stromal sarcoma,which was significant higher than that in leiomyosarcoma (68 2%)and mixed Mullerian tumour(3/6).③ There was positive correlation between ER and PR.ER and PR expression in patients with disease free survival were significant higher than in those died of sarcoma ( P <0 05).Conclusions There was significant difference of ER and PR expression among vary uterine sarcomas.ER and PR expression of disease free survival were significant higher than those died of sarcoma.ER and PR should be routinely estimated in uterine sarcoma, especially in endometrial stromal sarcoma.ER and PR can be a prognostic predictor for uterine sarcoma.
出处
《中国妇产科临床杂志》
2004年第2期116-119,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
首都医学发展科研基金 (首都ZD199911)资助
