摘要
目的分析和研究肝病并发自发性细菌性腹膜炎(SBP)的细菌耐药性,为临床使用抗生素提供参考。方法研究对象为我院收治的96例肝病合并SBP的患者,其性质为腹水细菌培养阳性,将其分为治疗组52例和对照组44例。对照组使用单一抗生素治疗;治疗组采用两种以上抗生素治疗。对其临床资料、腹水细胞的培养、药物敏感试验等结果进行分析和研究。结果两种以上抗生素治疗较单一抗生素治疗疗效显著。所有患者中67例革兰氏阴性菌(69.8%);21例革兰氏阳性菌(21.9%)。亚胺培南、阿米卡星及哌拉西林/三唑巴坦对革兰氏阴性菌较敏感;万古霉素、利奈唑胺对与革兰氏阳性菌较敏感。而其它如庆大霉素、头孢三代、喹诺酮类对革兰氏阴性菌和革兰氏阴性菌敏感度都较低。结论腹水细菌培养阳性的肝病合并SBP患者,其腹水病原菌主要是革兰氏阴性菌,并且有较强的耐药性。肝病合并SBP患者抗生素的使用应根据药物敏感试验报告来选用,更有效地治疗SBP。
Objective To analyse and study the liver disease complicated with spontaneous bacterial peritonitis (SBP) of bacterial resistance to antibiotics,to provide clinical reference. Methods Research for patients in our hospital treated 96 cases of liver disease complicated with SBP, the nature of ascites bacterial culture positive, divided into the treatment group of 52 cases and a control group of 44 cases. The control group using a single antibiotic (three generation cephalosporins) treatment;treatment group with more than two kinds of antibiotics (three generation cephalosporins) treatment.The clinical data, ascites cells in culture,drug sensitive test results analysis and research. Results 2 more after antibiotic treatment is single antibiotic treatment has obvious curative effect.For al patients, including 67 cases of Gram-negative bacteria(69.8%);21 cases with Gram-positive bacteria (21.9%). Imipenem, Amikacin and piperacil in/tazobactam for leather, three were gram-negative patients are more sensitive to vancomycin, linezolid; and leather, Gram-positive bacteria were more sensitive. Others such as gentamicin, three generations of cephalosporins, quinolones for Gram-negative and Gram-negative bacteria for patients with lower sensitivity. Conclusion Ascites bacterial culture positive liver disease in patients with SBP, its main ascites pathogens were Gram-negative bacteria, and has strong resistance. The use of antibiotics in patients with liver disease with SBP should be according to the drug sensitivity test to select. For more effective treatment of SBP.
出处
《中国药物经济学》
2013年第S1期45-47,共3页
China Journal of Pharmaceutical Economics
关键词
耐药性
抗生素
细菌感染
肝病
自发性细菌性腹膜炎
Drug resistance
Antibiotics
Bacterial infection
Liver disease
Spontaneous bacterial peritonitis
