摘要
肾素-血管紧张素系统在糖尿病视网膜病变(DR)的发生、发展中具有非常重要的作用。ACE2-Ang-(1-7)-Mas轴是近年来发现的肾素-血管紧张素系统的另一重要分支,能够对抗传统的ACE-AngⅡ-AT1轴,发挥改善胰岛素抵抗,舒张血管,调节眼压,抗氧化应激,保护血管内皮细胞,抗炎作用,从而对DR具有一定的保护作用。
Renin-angiotensin system ( RAS ) plays a very important role in the occurrence and development of diabetic retinopathy (DR).ACE2-Ang-(1-7)-Mas axis is another important branch of RAS, which is discovered recently.It can resist the traditional ACE-AngⅡ-AT1-axis.Its effects include improve insulin resistance, diastolic blood vessels, regulating intraocular pressure, against oxidative stress, protecting vascular endothelial cells, anti-inflammatory effects, which will be protective to DR.
出处
《中华眼科医学杂志（电子版）》
2013年第1期34-37,共4页
Chinese Journal of Ophthalmologic Medicine(Electronic Edition)
