摘要
目的建立测定大鼠血浆中阿托伐他汀含量的高效液相色谱法,研究黄精多糖对阿托伐他汀在大鼠体内药代动力学的影响。方法采用高效液相法测定大鼠灌胃给予阿托伐他汀(对照组)及阿托伐他汀+黄精多糖(试验组)后血浆中的阿托伐他汀浓度,经DAS2.11软件计算药动学参数。结果对照组与试验组血药浓度-时间值经DAS2.11软件处理,根据各组数据统计对照组与试验组的主要药动学参数,结果表明,对照组与试验组在大鼠体内的各项药代动力学参数差异无统计学意义。结论黄精多糖对阿托伐他汀在大鼠体内的药代动力学无明显影响。
Objective To establish a HPLC method for the determination of atorvastatin level in plasm of rats,and study the influence of polygahatous polysaccharides(PSP) on pharmacokinetics of atorvastatin in vivo. Methods The concentrations of Atorvastatin of plasma in Atorvastatin(control group) and Atorvastatin + PSP(experimental group) were determined by HPLC,and the pharmacokinetic parameters were calculated. Results After calculating pharmacokinetic parameters,we found there was no statistical difference between the two groups. Conclusion PSP has no significant on pharmacokinetics in vivo of atorvastatin in Rats.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第5期171-173,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
南京医科大学科技发展基金(2012NJMU227)
