摘要
目的 评价b型流感嗜血杆菌疫苗(Hib)流行病学保护效果.方法 电子检索National Centerfor Biotechnology Information(NCBI,美国国家医学图书馆数据库)和Cochrane协作网图书馆等数据库,将有关接种Hib流行病学保护效果的研究纳入分析.使用RevMan5.1软件进行统计分析.结果 共纳入7篇文献,均为随机对照试验.Hib 对流感嗜血杆菌侵袭性疾病(Hib-D)保护效果(vE)为88％(95％CI:80％ ～93％),对流感嗜血杆菌脑膜炎(HIB-M)的VE为84％(95％CI:74％～93％).结论 接种Hib可以降低因Hib感染所致侵袭性疾病和脑膜炎的发病率,具有良好的保护效果.
Objective To evaluate vaccine protective efficacy(VE) of Haemophilus influenzae type b vaccine (Hib).Methods The studies of VE for Hlib were included by searching National Center for Biotechnology Information and Cochrane Library,and meta-analysis was made by RevMan5.1.Results A total of 7 studies were included,all of which were random clinical trial.The VE of Hib against invasive Hib disease(Hib-D) was 88 ％ (95 ％ CI:80％-93 ％).The VE of Hib against Hib Meningitis(Hib-M) was 84％(95％ CI:74％-93％).Conchusions Hib inoculation can gain a good protection against Hib-D and Hib-M,and also can reduce the incidence rate of relative diseases.
出处
《国际流行病学传染病学杂志》
CAS
2013年第3期-,共6页
International Journal of Epidemiology and Infectious Disease
基金
浙江省卫生厅2012年医药卫生平台重点资助计划
