摘要
We studied the functional changes of pulmonary surfactant （PS） in acutelung injury models produced by endotoxin injection (E.coli O<sub>55</sub>B<sub>5</sub>) in rats.The sur-face properties of the lung lavage liquid and the total phospholipids （TPL） ex-tracted from it were assessed on a modified Wilhelmy film balance.γ-A isothermof the lavage liquid revealed an increase in minimum surface tension and a de-crease in hysteresis area,recruitment index and stability index,whereas that ofTPL extracted from it did not show any change except for hysteresis area.Thesurface activity correlates positively with the TPL content but negatively with thetotal protein content in the lavage liquid.The findings indicated that there was adysfunction of PS in rats with the lung injury induced by endotoxin,suggestingthat the function deficiency of PS might be caused by decreased phospholipidsand increased proteins in the alveoli.
We studied the functional changes of pulmonary surfactant (PS) in acute lung injury models produced by endotoxin injection (E.coli O_(55)B_5) in rats.The sur- face properties of the lung lavage liquid and the total phospholipids (TPL) ex- tracted from it were assessed on a modified Wilhelmy film balance.γ-A isotherm of the lavage liquid revealed an increase in minimum surface tension and a de- crease in hysteresis area,recruitment index and stability index,whereas that of TPL extracted from it did not show any change except for hysteresis area.The surface activity correlates positively with the TPL content but negatively with the total protein content in the lavage liquid.The findings indicated that there was a dysfunction of PS in rats with the lung injury induced by endotoxin,suggesting that the function deficiency of PS might be caused by decreased phospholipids and increased proteins in the alveoli.
