摘要
The concentrations of central neuropeptides,somatostatin(SS) and substance-P (SP),were determined in the different brain regions of young-aged male rats after a long-term ad-m inistration of anticonvulsants Qingyangshen(QYS),Diphenylhydantoin(DPH),andCarbamazepine(CBZ).The results were compared with Pentylenetetrazol(PTZ)-inducedseizure model and normal saline-treated controls.No effects of QYS on the concentrationsof SS and SP were found in the rats of four-week or eight week groups.Both of DPH andPTZ increased the SS levels in the midbrain of rats in four-week gronp.DPH,CBZ,andPTZ also increased the SP levels in the cerebral cortex,striatum,and brain stem of rats ineight-week group.Our present data indicated that the central neuropeptides SS and SPwere involved in the processes of epilepsy and antiepilepsy.Since QYS did not influence thecontents of SS and SP after a long-term administration,it suggested that theanticonvulsant mechanism of QYS may be different from those of DPH and CBZ,i.e.itmay be not due to its effect on the central neuropeptide pathway.
The concentrations of central neuropeptides,somatostatin(SS) and substance-P (SP), were determined in the different brain regions of young-aged male rats after a long-term ad- m inistration of anticonvulsants Qingyangshen(QYS),Diphenylhydantoin(DPH),and Carbamazepine(CBZ).The results were compared with Pentylenetetrazol(PTZ)-induced seizure model and normal saline-treated controls.No effects of QYS on the concentrations of SS and SP were found in the rats of four-week or eight week groups.Both of DPH and PTZ increased the SS levels in the midbrain of rats in four-week gronp.DPH,CBZ,and PTZ also increased the SP levels in the cerebral cortex,striatum,and brain stem of rats in eight-week group.Our present data indicated that the central neuropeptides SS and SP were involved in the processes of epilepsy and antiepilepsy.Since QYS did not influence the contents of SS and SP after a long-term administration,it suggested that the anticonvulsant mechanism of QYS may be different from those of DPH and CBZ,i.e.it may be not due to its effect on the central neuropeptide pathway.
