摘要
本文通过体内外实验研究了苦豆碱抗细菌感染作用的机理。体外抑菌试验证明苦豆碱具有杀死或抑制侵袭性大肠杆菌(EIEC)生长的作用。体内试验,通过腹腔注射活的 EIEC 给小鼠,结果证明苦豆碱能提高小鼠注射 EIEC 后48h内的生存率、能增强小鼠从脾脏清除细菌的能力、能增加抗菌抗体的效价和提高红细胞免疫功能。因此,作者认为苦豆碱抗细菌感染作用的机理,除苦豆碱的直接杀菌或抑菌作用外,还可通过提高机体的免疫功能来实现。
Aloperine's inhibition test against enteroinvasive Escherichia coli(EIEC) was proved to be positive in vitro.Through intraperitoneal inoculation of viable EIEC to mice,the mechanism of aloperine's anti-bacterial infective effect was investigated in vivo.The results showed that aloperine enhanced mice's survival rate (within 48h)following the attack of EIEC infection, increased the bacteria-removal ability from mouse spleen,raised titers of anti-bacteuial antibodies and enhanced the immunologic function of mouse erythrocytes.The authors consider that the anti-bacterial infective effect of aloperine is due to an enhancement of immunocompetence besides a direct inhibitory or bactericidal effects in the experimental mice.
出处
《宁夏医科大学学报》
1991年第4期5-7,共3页
Journal of Ningxia Medical University
关键词
苦豆碱
抗细菌感染
抑菌作用
免疫功能
aloperine
anti-bacterial infection
bacteriostasis
immunocompetence
