摘要
回顾性分析1959年11月至1986年底行术前放疗D_T10～70Gy以上不同剂量的500例食管癌资料,发现随剂量增加,切缘残癌从10.3％降至1.7％(P<0.01),肿瘤放射的反应明显加重,重度反应率由11.5％上升至56.4％,手术切除率从71.6％升至87％,5年生存率也由21％提高到29.7％。在各组中以40Gy组疗效好,并发症和手术死亡率低,10～29Gy组与同期单纯手术治疗者结果相近,≥50Gy组生存率、手术切除率与40Gy组相似,但吻合口瘘发生率为7.5％。手术死亡率为10.2％高于40Gy组(5.8％与2.9％),结果为4OGy时,能改善疗效,不增加并发症和手术死亡率。
500 esophageal carcinoma patients treated from November 1959 to December 1986, by combined preoperative radiotherapy and surgery were analysed. The doses ranged from 10 to more than 70 Gy. As the tumor dose increased, the rate of positive stump was raduced from 10.3% to 1.7%(P<0.01), the rates of marked radio-response was increased from 71.6% to 87%, and the 5-year survival was also increased from 21% to 29.7% Among the various dose ranges, 40 Gy stood best with the lowest complication rate and operative mortality. 10-29 Gy was irrelevant, the ≥50 Gy group gave more fistulas and operative mortalities. 40 Gy could improve the results without jeopardizing the complication and operative mortality rates.
出处
《中华放射肿瘤学杂志》
CSCD
1992年第3期29-30,69,共3页
Chinese Journal of Radiation Oncology
