摘要
目的检测上皮间叶转化相关蛋白E-cadherin、β-catenin和Vimentin在三阴性乳腺癌中的联合表达及其与预后的关系。方法免疫组织化学分别检测E-cadherin、β-catenin和Vimentin在51例三阴性乳腺癌中的表达,分析其联合表达与预后的相关性。结果 E-cadherin或β-catenin表达的缺失或Vimentin表达的增高均为异常表达。3项均正常、1~2项不正常以及3项均不正常的病例数分别为1例(1.96%)、37例(72.55%)、13例(25.49%)。3项均不正常组的5年内无瘤生存较其他组明显缩短(Log rank检验,P【0.01)。结论上皮间叶转化相关蛋白E-cadherin、β-catenin和Vimentin的联合检测有助于区分三阴性乳腺癌的异质性。
Objective To investigate the relationship between expressions of epithelial-mesenchymal transition related proteins(E-cadherin, β-catenin and Vimentin) and prognosis in triple-negative breast cancer. Methods The expressions of E-cadherin, β-catenin as well as Vimentin were examined by immunohistochemistry in 51 patients with breast cancer. The relation between combined expression of 3 markers and prognostic signifi cance was analyzed. Results The loss of E-cadherin or β-catenin expression and over-expression of Vimentin were defined as abnormal expression. The cases with 3 markers normal expressions, 1-2 markers normal expressions, and 3 markers abnormal expressions were 1(1.96%), 37(72.55%) and 13(25.49%), respectively.Patients with abnormal expression of 3 markers had shorter disease free survival(DFS),compared with those without. Conclusion The combined expression of E-cadherin,β-catenin as well as Vimentin were useful in discriminating the heterogeneity of triple-negative breast cancer.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2014年第3期265-268,共4页
Cancer Research on Prevention and Treatment
基金
湖北省自然科学基金资助项目(2009CDB333)
武汉市科学技术计划资助项目(201271130453)
关键词
乳腺肿瘤
预后
上皮间叶转化
钙黏蛋白
Breast cancer
Prognosis
Epithelial–mesenchymal transition
E-cadherin
