摘要
目的:探讨乙型肝炎患者血清腺苷酸脱氨酶(ADA)与肝纤维化血清标志物透明质酸(HA)、层黏蛋白(LN)、Ⅳ型胶原(C-Ⅳ)及Ⅲ型前胶原(PCⅢ)检测的意义。方法:选择2011年8月至2012年12月海南省人民医院收治的30例乙型肝炎住院患者作为观察组,同期38例健康体检者为正常对照组,分别检测两组血清ADA活性,HA、LN、C-Ⅳ、PCⅢ水平。结果:观察组患者血清ADA活性,HA、LN、C-Ⅳ、PCⅢ水平明显高于正常对照组,两组比较,差异有统计学意义(P<0.01)。结论:测定乙型肝炎患者血清ADA的活性与HA、LN、C-Ⅳ、PCⅢ水平的变化,既能了解乙型肝炎患者肝脏损伤程度,又能反映肝纤维化趋势,对乙型肝炎患者肝纤维化早期进行诊断、治疗,减少肝硬化的发生及预后判断有着重要的临床意义。
Objective:To investigate the clinical significance of serum adenosine deaminase(ADA) and liver fibrosis-associated biomarkers,including hyaluronic acid(HA).Laminin(LN),type Ⅳ collagen(C-Ⅳ)and type Ⅲ pre-collagen(PC Ⅲ) in patients with hepatitis B.Methods:Between August 2011 and December2012,we recruited 30 patients with hepatitis B(observation group) and 38 healthy subjects(control group) who underwent health check-up in Hainan People' s Hospital.The levels of serum ADA,HA,LN,C-Ⅳ and PC Ⅲwere assayed.Results:The observation group yielded markedly higher levels of serum ADA activity,HA,LN,C-Ⅳ and PC Ⅲ(all P<0.01) compared with control group.Conclusion:The assay of serum ADA activity and changes in the levels of HA,LN,C-Ⅳ and PC Ⅲ may help determine the magnitude of hepatic injury and the trends towards liver fibrosis in patients with hepatitis B.These measurements should be considered as worthwhile for early diagnosis and treatment of liver fibrosis in hepatitis B and may be associated with reduced incidence rate of liver cirrhosis and improved prognosis.
出处
《广州医学院学报》
2014年第1期49-51,共3页
Academic Journal of Guangzhou Medical College
