摘要
目的探讨补肾活血方对膝骨性关节炎(KOA)的临床疗效及作用机制。方法选择肾虚血瘀型KOA病人42例,共58个膝关节患者,口服补肾活血方进行治疗。分别于治疗前、治疗1个疗程及2个疗程后进行膝关节功能评分;采集患膝关节液,双抗体夹心ELISA法测定白细胞介素-1β(IL-1β)、转化生长因子-β1(TGF-β1)的水平。结果治疗后患者膝关节功能评分明显提高,膝关节液中IL-1β水平逐渐下降,TGF-β1的水平逐渐升高,组间差异具有统计学意义(P<0.05)。结论补肾活血方可降低KOA患者关节液中IL-1β水平,升高TGF-β1水平,改善KOA患者膝关节活动功能。
Objective To observe the effects of Bushen Huoxue decoction on knee osteoarthritis(KOA) and explore its mechanism.Methods 42 KOA patients with kidney deficiency and blood stasis syndrome(58 knees) received Bushen Huoxu decoction,the knee functional scores were used to evaluate the re sults before the treatment,after one course of treatment and two course of treatment,the synovial fluid in knee joint was collected and the levels of IL-1β,TGF-β1 in synovial fluid were detected by double antibody sandwich ELISA method.Results After the treatment,the knee functional scores were significantly increased,the level of IL-1β was gradually decreased,the level of TGF-β1 was gradually increased,and the difference between groups was significant(P<0.05).Conclusion Bushen Huoxue decoction can decrease the level of IL-1β,increase the level of TGF-β1 in synovial fluid,and improve the knee joint active function of KOA patients.
出处
《福建中医药大学学报》
2013年第2期12-14,共3页
Journal of Fujian College of Traditional Chinese Medicine
基金
福建省教育厅科技项目(JB09157)
