摘要
目的观察特利加压素联合大剂量白蛋白治疗老年肝肾综合征患者的疗效及安全性。方法 30例患者随机分为对照组(13例)和试验组(17例)。在内科综合治疗基础上,对照组予小剂量多巴胺联合大剂量白蛋白治疗;试验组使用特利加压素联合大剂量白蛋白,均连续使用7～14d。观察患者临床症状、尿量、血肌酐、尿素氮、腹水消长情况、不良反应、终止治疗事件及治疗后的转归。结果试验组患者与治疗前相比,治疗1d后尿量明显增加(P<0.01),血肌酐、尿素氮水平明显下降(P<0.05)。治疗第7天后比第3天后尿量进一步增加,血肌酐、尿素氮进一步降低(P<0.05)。同时患者腹水亦有所消退。而对照组患者治疗前后尿量、血肌酐及尿素氮水平无明显变化(P>0.05)。结论特利加压素联合大剂量白蛋白能有效治疗肝肾综合征,为老年肝肾综合征患者提供了一条安全有效的治疗途径。
Objective To observe the clinical effect and toxicity of terlipressin with large dose of albumin in management of the elderly patients with hepatorenal syndrome. Methods Thirty patients were divided into control group(13 cases)and experiment group(17 cases).Based on conventional treatment, low-dose dopamine with large-dose albumin were used in control group, and terlipressin with large-dose albumin were used in experiment group.The clinical symptoms,urine volume,serum creatinine,urea nitrogen and ascites,toxic reactions were observed. Results Compared with pre-therapy,the urine volume of patients was obviously increased(P<0.01)and serum creatinine, urea nitrogen were obviously declined at day 1 in treatment group(P<0.05).At day 7,the urine volumes were more than those at day 3(P<0.05).The levels of serum creatinine and urea nitrogen were less than those at day 3(P<0.05).At the same time,the ascites of patients were decreased in treatment group.However,there were no obvious changes in control group(P>0.05). Conclusions Combination of terlipressin and large-dose albumin is effective on hepatorenal syndrome, and it provides a safe and effective way for the treatment of the elderly patients.
出处
《实用老年医学》
CAS
2013年第1期41-43,共3页
Practical Geriatrics
