摘要
目的探讨syncytin在正常妊娠及子痫前期胎盘组织中的表达及意义。方法采用荧光实时定量PCR(Real-time FQ-PCR)方法检测正常晚期妊娠(20例)、晚发型子痫前期轻度(20例)、重度(25例)及早发型重度子痫前期(15例)胎盘组织中syncytin mRNA表达。结果 Syncytin mRNA在正常妊娠晚期及子痫前期胎盘组织中均有表达;晚发型子痫前期与正常晚孕比较,胎盘组织syncytin mRNA表达降低,且与病情严重程度相关;早发型与晚发型比较,早发型重度子痫前期表达降低更为明显,差异有统计学意义(P<0.01)。结论 Syncytin mRNA在子痫前期胎盘组织中表达降低,早发型降低更为明显,而syncytin与滋养细胞融合有关,提示滋养细胞融合障碍可能在子痫前期发病中发挥作用。
Objective To detect the expression and significance of syncytin mRNA in placenta of pre-eclampsia and normal pregnancy.Methods The expression of syncytin mRNA in placenta of 45 late-onset pre-eclampsia patients(20 cases of mild pre-eclampsia and 25 cases of severe pre-eclampsia),15 early-onset severe pre-eclampsia and 20 normal pregnant women was determined by Real-time FQ-PCR.Results Syncytin mRNA was expressed in placenta of normal and pre-eclampsia;it was significantly decreased in late-onset pre-eclampsia than in normal placenta,and the expression level was related to the severity of pre-eclampsia.Syncytin mRNA was significantly lower in early-onset severe pre-eclampsia than in late-onset pre-eclampsia placenta(P<0.01).Conclusion Syncytin mRNA has a lower expression in placenta of pre-eclampsia,especially in early-onset severe pre-eclampsia;and expression of syncytin is related to trophocyte fusion,suggesting that disorder of trophocyte fusion may play a role in the pathogenesis of pre-eclampsia.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2012年第1期104-106,113,共4页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
陕西省科技攻关项目(No.2007k13)~~
