摘要
目的比较高频条件下SonoVue与Sonazoid在不同机械指数(MI)下对兔肝超声造影的效果。方法在高频(7MHz)条件下,分别对8只新西兰大白兔多次团注SonoVue(0.06mL/kg)及Sonazoid(0.045mL/kg)进行超声造影。SonoVue组分别设置7个MI值(0.10、0.15、0.25、0.30、0.40、0.50、0.55),Son-azoid组分别设置5个MI值(0.19、0.40、0.62、0.78、0.98)。应用时间-强度曲线(TIC)进行定量分析,并分析兔肝超声造影增强效果及灌注参数与MI值的相关性。结果在相同发射频率(7MHz)条件下,SonoVue组随着MI值逐渐升高,峰值强度(PI)呈上升趋势,于MI=0.15时达最大值;同时,当MI≤0.25时,其TIC上升时间(RT)、达峰时间(TTP)较为稳定(P>0.05);之后随着MI值的增大,RT、TTP呈下降趋势(P<0.01)。Sonazoid组随着MI值逐渐升高,PI呈上升趋势,于MI=0.40时达最大值;同时,随着MI值的逐渐升高,其RT、TTP未见明显变化(P>0.05)。结论 SonoVue与Sonazoid理化特性不同,高频(7MHz)条件不同MI下其肝脏超声造影效能各不相同。
Objective The contrast enhancement of SonoVue and Sonazoid were compared in rabbit s liver with ultrasound frequency of7 MHz usinga rangingmechanical index(MI).Methods In the high frequency state (7 MHz),a total of 8 rabbits (weight 2.30±0.30 kg) were bolus injected with two contrast agents:Once the SonoVue (0.06 mL/kg) was injected,the MI was observed ranging from0.10 to0.55 (0.10,0.15,0.25,0.30,0.40,0.50,0.55);after injection of Sonazoid (0.045 mL/kg),MI was found ranging from 0.19 to 0.98 (0.19,0.40,0.62...
出处
《中华医学超声杂志（电子版）》
2011年第5期958-967,共10页
Chinese Journal of Medical Ultrasound(Electronic Edition)
关键词
超声检查
造影剂
机械指数
Ultrasonography
Contrast media
Mechanical index
