摘要
目的分析轻度认知功能障碍(MCI)病人双侧海马生化代谢改变,探讨氢质子波谱成像(1 H-MRS)在MCI诊断中的应用价值。方法选择MCI病人(MCI组)和正常对照(NC组)各22例,均行双侧海马1 H-MRS检查,计算双侧海马N-乙酰天冬氨酸(NAA)/肌酸(Cr)、肌醇(mI)/Cr、胆碱(Cho)/Cr及NAA/mI。对MCI组病人双侧海马NAA/Cr、mI/Cr及NAA/mI值与蒙特利尔认知评估量表(MoCA)总分及各亚项得分作相关性分析。结果与NC组比较,MCI组病人NAA/Cr、NAA/mI降低(t=2.51、2.86,P<0.05),mI/Cr增高(t=2.47,P<0.05),MoCA总分及延迟记忆得分降低(t=17.47、2.56,P<0.05)。MCI组NAA/Cr、NAA/mI分别与MoCA总分、延迟记忆得分呈正相关(r=0.57~0.68,P<0.01),mI/Cr与MoCA总分、延迟记忆得分呈负相关(r=-0.54、-0.54,P<0.01)。结论 1 H-MRS能够早期检测MCI病人海马区的生化代谢改变,在MCI早期诊断中具有重要价值。
Objective To investigate the changes of biochemical metabolites in bilateral hippocampus in patients with mild cognitive impairment （MCD, and assess the value of hydrogen MRS （1H-MRS） in the diagnosis of this disease. Methods Twenty-two MCI patients and 22 normal subjects were enrolled. Bilateral hippocampus was examined with 1 H-MRS in all of them. N-aeetylaspartate （NAA）/creatine （Cr）, choline （Cho）/Cr, myo-inositol （mI）/Cr, and N-acetylaspartate （NAA）/mI, in bilate- ral hippocampus, were calculated. A correlation analysis was done between the value of NAA/Cr, Cho/Cr, mI/Cr, NAA/ mI and total score of MoCA and its sub-item score. Results Compared with normal controls, the levels of NAA/Cr and NAA/mI in the patients declined （t =2.51,2.86 ;P^0.05）, and mI/Cr increased （t = 2.47, P〈0.05）, total score of MoCA and delayed memory scores declined （t = 17.47,2.56;P〈0.05）. In the patients, the values of NAA/Cr and NAA/mI were positively correlated with to- tal score of MoCA and delayed memory scores （r = 0.57--0.68, P〈0.01）, and mI/Cr was negatively correlated with MoCA total score and delayed memory scores （r=--0.54, --0.54;P〈0.01）. Conclusion 1H-MRS can detect early biochemical metabolic changes of hippocampus in patients with mild cognitive impairment, which has important value in early diagnosis of this lesion.
出处
《齐鲁医学杂志》
2016年第2期207-209,212,共4页
Medical Journal of Qilu
关键词
认知障碍
海马
磁共振波谱学
cognition disorders
hippocampus
magnetic resonance spectroscopy
