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血液灌流对重症急性中毒患者的影响

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摘要 [目的]研究血液灌流(HP)对重症中毒患者炎症介质的影响。[方法]收集43例杭州师范大学附属医院重症药物中毒并行HP患者。检测患者HP前后炎症介质IL-1、IL-2、IL-6、IL-8和TNF-α含量变化。[结果]与HP前相比,所检测的炎症介质在HP第1h均显著下降(P<0.01)。在接下来的时间各炎症介质出现不同程度的反跳。IL-6在24h后反跳。TNF-α、IL-2除在第2h出现明显反跳,在其他时间仍显示下降趋势。而IL-1和IL-8从第2h开始反跳明显,到达甚至超过灌流前水平(P>0.05)。[结论]HP治疗对改善SIRS反应有积极作用,但是部分炎症介质在HP治疗一段时间后出现反弹,达到甚至超过灌流水平。其应对方法有待进一步的探讨。
出处 《浙江中医药大学学报》 CAS 2010年第6期926-927,共2页 Journal of Zhejiang Chinese Medical University
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