摘要
The production of 7-aminodeacetoxy cephalosporanic acid (7-ADCA),4′-nitrobenzyl-3-bromomethyl-3-cephem-4-carboxylate(GCLE) and their analo-gues from penicillin G. K. is an important national project for the new drug development. In this project 7-ADCA is produced by oxidation, ring expansion and enzyme splitting reaction of penicillin G,K(Scheme 1).……
