摘要
Objective:To investigate the effect of prostaglandin E1 (PGE1) (Alprostadii injection) on patients with primary nephrotic syndrome(PNS). Methods: 37 patients with PNS were recruited to study the effect of prostaglandin E1 on platelet aggregation function [ PAG (5,) PAG( m ) ], serum total protein (TP) , albumin (Al),blood urea nitrogen(BUN) ,serum creatinine(Scr) ,cholesterol(CHO), triglyceride(TG), protein in 24-hour urine (Pr/24h) and platelet account (PLT). Results: TP, Al, CHO, TG, BUN, Scr, Pr/24h, PAG(5) and PAG(m) in PNS group before treatment were significantly different from those in control group(P＜0.05, P＜0.01) while no significant difference was found for PLT. When treated with PGE1 , TP,Al,CHO, TG, Pr/24h, ADP- induced PAG(5) ,and Adr- induced PAG(5) and PAG(m) were significantly different from those before treatment (P＜0.05). Adr- induced PAG(5) and PAG(m) were significantly different. Adr- induced PAG(5) was xsitively correlated with BUN and Scr in PNS(P＜0.01). Similar correlation was found between ADP-induced PAG(5) and Al ,BUN,Scr,Pr/24h(P＜0.05), AD- induced PAG(m) and TP,CHO(P＜0.05). Conclusions: PGE1 may be an effective drug for the treatment for hypercoagulation in patients with PNS.
Objective:To investigate the effect of prostaglandin E1 (PGE1) (Alprostadii injection) on patients with primary nephrotic syndrome (PNS). Methods: 37 patients with PNS were recruited to study the effect of prostaglandin E1 on platelet aggregation function [PAG(5,)PAG(m)],serum total protein(TP) ,albumin(Al), blood urea nitrogen(BUN),serum creatinine(Scr) .cholesterol(CHO), triglyceride(TG), protein in 24 - hour urine (Pr/24h) and platelet account(PLT). Results:TP, Al,CHO.TG,BUN,Scr,Pr/24h, PAG(5) and PAG(m) in PNS group before treatment were significantly different from those in control group(P<0.05, P<0.01) while no significant difference was found for PLT. When treated with PGEI , TP, Al.CHO,TG, Pr/24h, ADP- induced PAG(5),and Adr- induced PAG(5) and PAG(m) were significantly different from those before treatment (P< 0.05). Adr- induced PAG(5) and PAG(m) were significantly different. Adr- induced PAG(5) was positively correlated with BUN and Scr in PNS(P<0.01). Similar correlation was found between ADP-induced PAG(5) and Al ,BUN,Scr,Pr/24h(P<0.05), AD-induced PAG(m) and TP,CHO(P<0. 05). Conclusions: PGEI may be an effective drug for the treatment for hypercoagulation in patients with PNS.
出处
《中国医学工程》
2002年第6期37-39,共3页
China Medical Engineering
基金
This work is supported by grant from Beijing Tide Pharmaceutical Co,Ltd.
