摘要
目的探讨对氧磷脂酶-1(paraoxonase-1,PON-1)的基因多态性与颅内大动脉粥样硬化性狭窄或闭塞的相关性。方法对53例伴有颅内大动脉粥样硬化性狭窄或闭塞的首发急性脑梗死患者(病例组)和55例年龄、性别匹配的健康者(对照组)进行PON-1基因型研究。结果病例组和对照组PON-1 Q192R QQ、QR、RR三种基因型分布间差别无显著性意义(X^2=5．96,P＞0．05),但病例组R等位基因频率高于对照组(分别为0．77,0．62,X^2 =5．49,P＜0．05)。多因素LoGIstic回归分析表明,R等位基因可增加颅内动脉粥样硬化的发生风险(OR=1．51, 95% CI 1．13～2．03,P＜0．05)。结论R等位基因是河北地区汉族人颅内大动脉粥样硬化的危险因素;R等位基因与糖尿病、吸烟可发生协同作用,可增加糖尿病、吸烟对颅内动脉粥样硬化的发生风险。
Objective To explore the relation between the Q192R polymorphism of paraoxonase-1 and acute ische- mic stroke with intracranial atherosclerosis stenosis.Methods A case-control study on 53 patients with symptomatic intracrani- al atherosclerosis stenosis and 55 age-and gender-matched health individuals was carried out.Results The frequencies of Q and R alleles for the PON-1 Q192R polymorphism was 0.23 and 0.77 respectively in study group and was 0.38,0.62 in control group.No differences were found in PON-1 gene QQ,QR and RR genotype between the two groups,but there was significant differences in R allele frequency between study group and control group(P＜0.05).Our study demonstrated that R allele was a main determinant of intracranial atherosclerosis stenosis through multivariate logistic regression analysis(OR 1.51 95% CI 1.13～2.03).Conclusion Our data indicate that R allele of the PON-1 is a risk factor for intracranial atherosclerosis stenosis in HeBei Han nationality.There is an interaction between R allele gene and smoking or diabetes for increasing risk of intracranial atherosclerosis stenosis.
出处
《中国卒中杂志》
2006年第1期21-22,26,共3页
Chinese Journal of Stroke
