摘要
目的评价盐酸戊乙奎醚(长托宁)在COPD急性发作期降低肺动脉压进而改善肺功能的疗效。方法将60例COPD急性发作期患者随机分为两组:治疗组30例,对照组30例,治疗组雾化吸入长托宁,对照组雾化吸入喘定。分别测定两组患者用药前后不同时期最大呼气流速(PEF)、第一秒用力呼气量(FEV1),动脉血气的变化及超声心动测定肺动脉压的变化。结果治疗组肺动脉压下降20%,对照组肺动脉压下降5%～7%,两组比较差异有统计学意义(P<0.05)。用药后FEV1和PEF改善,均P<0.000。动脉血气在用药后明显改善,PaO2上升16mmHg(P<0.000);PaCO2下降8mmHg,但与对照组比较差异无显著性(P>0.05)。呼吸频率用药30min后明显减慢(P<0.01)。咳嗽、咳痰量、肺部音评分在用药后出现改善,第三天评分值最低(P<0.01)。结论长托宁在改善AECOPD患者的症状、体征、降低肺动脉压从而改善肺功能方面具有较好的疗效。
Objective To investigate the effects of penehyclidine hydrochloride(PHC),an anticholinergic bronchodilator developed in China,in treatment of acute exacerbations of chronic obstructive pulmonary disease(AECOPD).Methods Sixty AECOPD patients,31 males and 29 females,aged around seventy,with the duration of about 25 years,were randomly divided into 2 equal groups:PHC group,inhaling PHC I mg bid;and control group,inhaling glyphylline 0.25 g bid.Pulmonary artery pressure,PaO2,and PaCO_2 were measured before and(Time)after the inhalation.Symptoms and signs were observed,and heart rate,respiratory rate,peak expiratory flow(PEF)and forced expiratory volume in one second(FEV1),were measured before and 15 min,30 min,60 min,120 min,2 d,and 3d after the inhalation.Results Before inhalation,the pulmonary artery pressure was not significantly different between the 2 groups,however,after the inhalation the pulmonary artery pressure of the PHC group was 43.22±9.74 mmHg(reduced by 20%),significantly lower than that of the control group(47.56±9.40,reduced by 5%～7%)(P<0.05).The values of FEV1 of the 2 groups at different time points all increased,however,the values since 30 min after the inhalation of the PHC group were all significantly higher than those of the control group(P<0.05 or P<0.01).The values of PEF of the 2 groups at different time points all increased,however,the values since 60 min after the inhalation of the PHC group were all significantly higher than those of the control group(all P<0.05).The values of PaO_2 and PaCO_2 before inhalation of the 2 groups were not significantly different.The PaO_2 value after inhalation of the PHC group was significantly higher than that of the control group(P<0.01).The PaCO_2 values after inhalation of the 2 groups both decreased,however,without a significant difference between these 2 groups(P>0.05).The heart rates,respiratory rates,and symptom and sign scores at different time points of the 2 groups all significantly reduced compared with those before the inhalation(all P<0.05
出处
《中国急救复苏与灾害医学杂志》
2006年第6期202-205,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
关键词
盐酸戊乙奎醚
慢性阻塞性肺疾病
急性加重期
肺功能
肺动脉压
Penehyclidine hydrochloride
Acute exacerbations of chronic obstructive pulmonary disease
Lung function
Pulmonary artery pressure
