摘要
目的探讨超声对动脉粥样硬化模型SD大鼠主动脉病变的诊断价值。方法把44只雄性SD大鼠随机分成对照组11只和实验组33只,实验组喂高脂饲料+0.2%丙基硫氧嘧啶,对照组喂基础饲料。3个月后对所有大鼠行超声检查,观察升主动脉、主动脉弓、降主动脉、腹主动脉内中膜变化,超声观察后处死大鼠并行病理学检查,观察主动脉管壁病理改变。结果饲养3个月后对照组大鼠主动脉全程超声及病理学检查均未发现明显病变,实验组大鼠升主动脉、主动脉弓、降主动脉、腹主动脉可见动脉粥样硬化病变,即超声表现为主动脉管壁内膜偏心性增厚、不光滑、连续性中断,病理表现为主动脉壁增厚、平滑肌细胞增生、细胞排列紊乱、弹性纤维层结构不清及局部管壁向管腔内突出。结论超声可准确检测动脉粥样硬化模型SD大鼠的主动脉内中膜病变。
Objective To establish an experimental model of atherosclerosis in Sprague Dawley rats,to study the atherosclerotic lesions in the aorta with ultrasound and to evaluate echocardiographic diagnosis in Sprague Dawley rat atherosclerosis.Methods The 33 rats in the experimental group were loaded with high fat diet;the control group(11 rats) was given basic food.The pathological and ultrasonic changes were observed in the inner membrane of aorta in the 44 rats after 3 months.Results There were no significant differences in the aorta in the control group on ultrasound and in pathology,but were significant differences in the aorta in the experimental group.Comparison of ultrasound features with pathology showed that the aortic wall plagues in the experimental group were sensitively detected in both ultrasound and pathology.Conclusions Ultrasound can accurately measure the aortic inner membrane,and dynamically monitor the changes of the rat aortic inner membrane.
出处
《中华医学超声杂志（电子版）》
2007年第6期332-333,共2页
Chinese Journal of Medical Ultrasound(Electronic Edition)
关键词
超声检查
动脉硬化
动物模型
Ultrasonography
Arteriosclerosis
Animal model
