摘要
目的探讨肺癌组织中低氧诱导因子1α(HIF-1α)、多药耐药相关蛋白1(MRP1)和谷胱甘肽S转移酶-π(GST-π)的表达及其相关性。方法采用免疫组织化学方法检测53例肺癌组织中HIF-1α、MRP1和GST-π的表达水平。比较不同肺癌浸润程度、有无淋巴结转移者HIF-1α、MRP1和GST-π的阳性表达情况。结果53例肺癌组织中HIF-1α阳性表达44例(83.0%),GST-π阳性表达28例(52.8%),两者呈正相关(P<0.05),HIF-1α表达与MRP1表达(阳性表达31例,为58.5%)无相关性(P>0.05)。肺癌TNM分期T3、T4组HIF-1α、MRP1和GST-π高表达率分别为60.0%、80.0%和73.3%,与T1、T2组的26.3%、44.7%和42.1%比较,差异均有统计学意义(P<0.05)。肺癌有淋巴结转移组HIF-1α、MRP1和GST-π高表达率分别为84.0%、72.0%、68.0%,与无淋巴结转移组的25.0%、42.9%和39.3%比较,差异均有统计学意义(P<0.05)。结论HIF-1α可能对GST-π的表达起上调作用,HIF-1α、MRP1和GST-π高表达与肺癌的浸润程度和淋巴结转移有关。
Objective To investigate the expressions of hypoxia induced factor 1α(HIF-1α),multidrug resistance related protein1(MRP1)and glutathione S-transferase pi(GST-π)in lung cancer tissue,and the correlation among them.Methods The expressions of HIF-1α,MRP1 and GST-π were tested by immunohistochemical method in lung cancer specimens of 53 patients.The relationships of their positive expressions to invasion degree and lymphatic metastasis of lung cancer were analyzed.Results In specimens of 53 lung cancer patients...
出处
《中国全科医学》
CAS
CSCD
北大核心
2009年第7期549-550,553,共3页
Chinese General Practice
关键词
肺肿瘤
低氧诱导因子1Α
多药耐药相关蛋白
谷胱甘肽转移酶
Lung neoplasms
Hypoxia induced factor 1α
Multidrug resistance associated proteins
Glutathione transferase
